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Drug ReportsTenofovir disoproxil
Viread(tenofovir disoproxil)
Cimduo, Complera, Delstrigo, Efavirenz / / Tenofovir Disoproxil, Efavirenz / Emtricitabine / Tenofovir Disoproxil, Emtricitabine / Tenofovir Disoproxil, Eviplera, Stribild, Symfi, Tenofovir Disoproxil, Truvada, Viread (tenofovir disoproxil) is a small molecule pharmaceutical. Tenofovir disoproxil was first approved as Viread on 2001-10-26. It is used to treat chronic hepatitis b and HIV in the USA. It has been approved in Europe to treat chronic hepatitis b and HIV infections.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Tenofovir disoproxil, Viread (discontinued: Tenofovir disoproxil)
Combinations
Cimduo, Complera, Delstrigo, Efavirenz, emtricitabine, tenofovir disoproxil, Efavirenz, lamivudine tenofovir disoproxil, Emtricitabine tenofovir disoproxil, Emtricitabine, rilpivirine tenofovir disoproxil, Stribild, Symfi, Symfi lo, Truvada (discontinued: Atripla, Efavirenz, lamivudine tenofovir disoproxil, Efavirenz; emtricitabine tenofovir disoproxil, Efavirenz; emtricitabine; tenofovir disoproxil, Emtricitabine tenofovir disoproxil, Lamivudine tenofovir disoproxil, Temixys)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
CIMDUOMylanN-022141 RX2018-02-28
1 products, RLD, RS
Show 2 discontinued
Efavirenz
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
SYMFI LOMylanN-208255 RX2018-02-05
1 products, RLD, RS
SYMFIMylanN-022142 RX2018-03-22
1 products, RLD, RS
Show 2 discontinued
Doravirine
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
DELSTRIGOMerck & CoN-210807 RX2018-08-30
1 products, RLD, RS
Efavirenz
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
ATRIPLAGilead SciencesN-021937 DISCN2006-07-12
1 products, RLD
Hide discontinued
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
COMPLERAGilead SciencesN-202123 RX2011-08-10
1 products, RLD, RS
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
STRIBILDGilead SciencesN-203100 RX2012-08-27
1 products, RLD, RS
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
TRUVADAGilead SciencesN-021752 RX2004-08-02
4 products, RLD, RS
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
VIREADGilead SciencesN-021356 RX2001-10-26
4 products, RLD, RS
VIREADGilead SciencesN-022577 RX2012-01-18
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
atriplaNew Drug Application2017-01-23
atripla accessExport only2021-04-12
cimduoNew Drug Application2021-02-15
compleraNew Drug Application2024-09-24
complera accessExport only2024-09-23
delstrigoNew Drug Application2025-01-28
efavirenz, emtricitabine and tenofovir disoproxil fumarateANDA2024-06-27
efavirenz, lamivudine and tenofovir disoproxil fumarateANDA2024-05-07
emtricitabine and tenofovir disoproxil fumarateANDA2025-06-03
emtricitabine, rilpivirine, tenofovir disoproxil fumarateANDA2024-12-14
Show 10 more
Agency Specific
FDA
EMA
Expiration
Code
DORAVIRINE / LAMIVUDINE / TENOFOVIR DISOPROXIL FUMARATE, DELSTRIGO, MSD MERCK CO
2025-01-27NPP
2023-08-30NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Doravirine / Lamivudine / Tenofovir Disoproxil Fumarate, Delstrigo, Msd Merck Co
106032822036-11-29DP
108427512036-11-29DP
84869752031-10-07DS, DPU-2395, U-2629, U-3307
Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Disoproxil Fumarate, Complera, Gilead Sciences Inc
108571022033-01-14DP
88413102025-12-09DPU-257
71258792025-04-21DS, DPU-257
80805512023-04-11DS, DP
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate, Stribild, Gilead Sciences Inc
100397182032-10-06DP
86332192030-04-30DPU-257
81483742029-09-03DS, DPU-1279
98912392029-09-03DPU-257
76357042026-10-26DS, DPU-257
89811032026-10-26DS, DP
71762202026-08-27DS, DPU-257
85923972024-01-13DPU-248, U-257, U-541, U-750, U-1170
87162642024-01-13DPU-257
94570362024-01-13DPU-257
97441812024-01-13DPU-257
Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate, Atripla, Gilead Sciences
85981852029-04-28DP
90181922026-06-13U-750, U-1170
95454142026-06-13DPU-750, U-1170
ATC Codes
J: Antiinfectives for systemic use
J05: Antivirals for systemic use
J05A: Direct acting antivirals
J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF07: Tenofovir disoproxil
J05AR: Antivirals for treatment of hiv infections, combinations
J05AR03: Tenofovir disoproxil and emtricitabine
J05AR06: Emtricitabine, tenofovir disoproxil and efavirenz
J05AR08: Emtricitabine, tenofovir disoproxil and rilpivirine
J05AR09: Emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat
J05AR11: Lamivudine, tenofovir disoproxil and efavirenz
J05AR12: Lamivudine and tenofovir disoproxil
J05AR24: Lamivudine, tenofovir disoproxil and doravirine
J05AR27: Lamivudine, tenofovir disoproxil and dolutegravir
HCPCS
No data
Clinical
Clinical Trials
1338 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2021320121057
HivD006678O98.72310318
Acquired immunodeficiency syndromeD000163EFO_0000765B201373317
InfectionsD007239EFO_0000544162514
Communicable diseasesD0031414149
Immunologic deficiency syndromesD007153D84.93216
Hepatitis bD006509213
HepatitisD006505K75.9213
Hepatitis aD006506EFO_0007305B15213
Body weightD001835EFO_0004338112
Show 10 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TuberculosisD014376EFO_0000774A15-A191113
Hiv-1D015497123
Hiv-2D01549811
Breast feedingD00194211
PregnancyD011247EFO_0002950Z33.111
Antibiotic prophylaxisD01907211
Virus diseasesD014777B3411
ObesityD009765EFO_0001073E66.911
Metabolic syndromeD024821EFO_0000195E88.81011
Body weight changesD00183611
Show 1 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437N1911
ViremiaD014766B34.911
Biliary liver cirrhosisD008105K74.311
CholangitisD002761HP_0030151K83.011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart disease risk factorsD00008274211
Metabolic diseasesD008659EFO_0000589E88.911
Lipid metabolism disordersD05243911
Healthy volunteers/patients11
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neurotoxicity syndromesD020258G9211
Neurocognitive disordersD019965F0911
Hepatitis cD006526B19.211
CoinfectionD06008511
Chemical and drug induced liver injuryD056486EFO_000422811
ProteinuriaD011507R8011
Hiv seropositivityD00667911
AgingD000375GO_0007568R41.8111
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTenofovir disoproxil
INN
Description
Tenofovir (anhydrous) is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. It has a role as a HIV-1 reverse transcriptase inhibitor, an antiviral drug and a drug metabolite. It is a member of phosphonic acids and a nucleoside analogue. It is a conjugate acid of a tenofovir(1-).
Classification
Small molecule
Drug classantivirals
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C
Identifiers
PDB
CAS-ID147127-20-6
RxCUI117466
ChEMBL IDCHEMBL1538
ChEBI ID63717
PubChem CID464205
DrugBankDB00300
UNII ID
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Stribild Gilead Sciences
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Complera Gilead Sciences
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Delstrigo Merck & Co
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Atripla Gilead Sciences
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Truvada Gilead Sciences
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Viread Gilead Sciences
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,569 documents
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Safety
Black-box Warning
Black-box warning for: Atripla, Atripla access, Cimduo, Complera, Complera access, Delstrigo, Efavirenz, emtricitabine and tenofovir disoproxil fumarate, Efavirenz, lamivudine and tenofovir disoproxil fumarate, Emtricitabine and tenofovir disoproxil fumarate, Emtricitabine, rilpivirine, tenofovir disoproxil fumarate, Stribild, Stribild access, Symfi, Symfi lo, Tenofovir disoproxil fumarate, Tenofovir disproxil fumarate, Truvada, Truvada access, Viread, Viread access
Adverse Events
Top Adverse Reactions
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86,833 adverse events reported
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